NASHVILLE, Tenn. (AP) — The head of Tennessee’s prison system is resigning, Gov. Bill Lee announced Saturday, the first major shake-up since the stunning failed execution of Christa Pike landed her on a ventilator at a hospital.

Frank Strada, commissioner of the Department of Correction, will step down this month, Lee said.

Strada said in a statement that resigning was “in the best interest of Tennesseans” while an independent review determines what happened Wednesday when the state failed to execute Pike despite administering two doses of a lethal drug.

“I believe this review is entirely appropriate and necessary, and I look forward to doing everything I can to help determine exactly what occurred,” Strada said.

Pike was taken to a hospital, where she was on a ventilator and unconscious in the following hours, her attorneys said in a court filing Friday.

Hospital staff were working to save Pike’s life and, as of late Thursday, were trying to clear the two doses of pentobarbital, which the state uses to execute prisoners, lawyers said.

The shocking failure has left both sides of the death penalty debate demanding answers. Lee has ordered an independent review and halted any new executions. Strada said he believes the state “carried out its responsibilities in accordance with the established protocol.”

Pike’s legal team welcomed Strada’s departure but said “it does nothing to help Christa now.”